Agents Classified by the IARC Monographs, Group 1

Agents Classified by the IARC Monographs, Volumes 1–104

Groupes d’évaluation – Définitions
Groupe 1 : L’agent est cancérogène pour l’homme.
Cette catégorie est utilisée lorsque l'on dispose d'indications suffisantes de cancérogénicité pour l'homme. Exceptionnellement, un agent peut être placé dans cette catégorie lorsque les indications de cancérogénicité pour l'homme sont moins que suffisantes, mais que l’on dispose d’indications suffisantes de sa cancérogénicité pour l'animal de laboratoire et de données probantes, chez l’homme exposé, selon lesquelles l'agent suit un mécanisme de cancérogénicité pertinent.

CAS No Agent Group Volume Year
000075-07-0 Acetaldehyde associated with consumption of alcoholic
beverages 1 100E 2012
Acid mists, strong inorganic 1 54, 100F 2012
001402-68-2 Aflatoxins 1 56, 82, 100F 2012
Alcoholic beverages 1 44, 96, 100E 2012
Aluminium production 1 34, Sup 7,
100F 2012
000092-67-1 4-Aminobiphenyl 1 1, Sup 7, 99,
100F 2012
Areca nut 1 85, 100E 2012
000313-67-7
Aristolochic acid
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 82, 100A 2012
000313-67-7 Aristolochic acid, plants containing 1 82, 100A 2012
007440-38-2 Arsenic and inorganic arsenic compounds 1 23, Sup 7,
100C 2012
001332-21-4
013768-00-8
012172-73-5
017068-78-9
012001-29-5
012001-28-4
014567-73-8
Asbestos (all forms, including actinolite, amosite,
anthophyllite, chrysotile, crocidolite, tremolite)
(NB: Mineral substances (e.g. talc or vermiculite) that
contain asbestos should also be regarded as
carcinogenic to humans.)
1 14, Sup 7,
100C 2012
Auramine production 1 Sup 7, 99,
100F 2012
000446-86-6 Azathioprine 1 26, Sup 7,
100A 2012
000071-43-2 Benzene 1 29, Sup 7.
100F 2012
000092-87-5 Benzidine 1 29, Sup 7,
99, 100F 2012
Benzidine, dyes metabolized to
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 99, 100F 2012
000050-32-8
Benzo[a]pyrene
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 92, 100F 2012
007440-41-7 Beryllium and beryllium compounds 1 58, 100C 2012
Betel quid with tobacco 1 85, 100E 2012
Betel quid without tobacco 1 85, 100E 2012
000542-88-1
000107-30-2
Bis(chloromethyl)ether; chloromethyl methyl ether
(technical-grade) 1 4, Sup 7,
100F 2012
000055-98-1 Busulfan 1 4, Sup 7,
100A 2012
000106-99-0 1,3-Butadiene 1 97, 100F 2012
007440-43-9 Cadmium and cadmium compounds 1 58, 100C 2012
000305-03-3 Chlorambucil 1 26, Sup 7,
100A 2012
000494-03-1 Chlornaphazine 1 4, Sup 7,
100A 2012
018540-29-9 Chromium (VI) compounds 1 49, 100C 2012
Clonorchis sinensis (infection with) 1 61, 100B 2012
Coal, indoor emissions from household combustion of 1 95, 100E 2012
Coal gasification 1 92, 100F 2012
008007-45-2 Coal-tar distillation 1 92, 100F 2012
065996-93-2 Coal-tar pitch 1 35, Sup 7,
100F 2012
Coke production 1 92, 100F 2012
000050-18-0
006055-19-2 Cyclophosphamide 1 26, Sup 7,
100A 2012
059865-13-3
079217-60-0 Cyclosporine 1 50, 100A 2012
000056-53-1 Diethylstilbestrol 1 21, Sup 7,
100A 2012
Epstein-Barr virus 1 70, 100B 2012
066733-21-9 Erionite 1 42, Sup 7,
100C 2012
Estrogen therapy, postmenopausal 1 72, 100A 2012
Estrogen-progestogen menopausal therapy (combined) 1 72, 91, 100A 2012
Estrogen-progestogen oral contraceptives (combined)
(NB: There is also convincing evidence in humans that
these agents confer a protective effect against cancer in
the endometrium and ovary)
1 72, 91, 100A 2012
000064-17-5 Ethanol in alcoholic beverages 1 96, 100E 2012
000075-21-8
Ethylene oxide
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 97, 100F 2012
033419-42-0
Etoposide
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 76, 100A 2012
033419-42-0
015663-27-1
011056-06-7
Etoposide in combination with cisplatin and bleomycin 1 76, 100A 2012
Fission products, including strontium-90 1 100D 2012
000050-00-0 Formaldehyde 1 88, 100F 2012
Haematite mining (underground) 1 1, Sup 7,
100D 2012
Helicobacter pylori (infection with) 1 61, 100B 2012
Hepatitis B virus (chronic infection with) 1 59, 100B 2012
Hepatitis C virus (chronic infection with) 1 59, 100B 2012
Human immunodeficiency virus type 1 (infection with) 1 67, 100B 2012
Human papillomavirus types 16, 18, 31, 33, 35, 39, 45,
51, 52, 56, 58, 59
(NB: The HPV types that have been classified as
carcinogenic to humans can differ by an order of
magnitude in risk for cervical cancer)
1 64, 90, 100B 2012
Human T-cell lymphotropic virus type I 1 67, 100B 2012
Ionizing radiation (all types) 1 100D 2012
Iron and steel founding (occupational exposure during) 1 34, Sup 7,
100F 2012
Isopropyl alcohol manufacture using strong acids 1 Sup 7, 100F 2012
Kaposi sarcoma herpesvirus 1 70, 100B 2012
CAS No Agent Group Volume Year
Leather dust 1 100C 2012
Magenta production 1 57, 99, 100F 2012
000148-82-3 Melphalan 1 9, Sup 7,
100A 2012
000298-81-7 Methoxsalen (8-methoxypsoralen) plus ultraviolet A
radiation 1 24, Sup 7,
100A 2012
000101-14-4
4,4'-Methylenebis(2-chloroaniline) (MOCA)
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 57, 99, 100F 2012
Mineral oils, untreated or mildly treated 1 33, Sup 7,
100F 2012
MOPP and other combined chemotherapy including
alkylating agents 1 Sup 7, 100A 2012
000091-59-8 2-Naphthylamine 1 4, Sup 7, 99,
100F 2012
Neutron radiation
(NB: Overall evaluation upgraded to Group 1 with
supporting evidence from other relevant data)
1 75, 100D 2012
Nickel compounds 1 49, 100C 2012
016543-55-8
064091-91-4
N'-Nitrosonornicotine (NNN) and 4-(NNitrosomethylamino)-
1-(3-pyridyl)-1-butanone (NNK)
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 89, 100E 2012
Opisthorchis viverrini (infection with) 1 61, 100B 2012
Painter (occupational exposure as a) 1 47, 98, 100F 2012
057465-28-8
3,4,5,3’,4’-Pentachlorobiphenyl (PCB-126)
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 100F 2012
057117-31-4
2,3,4,7,8-Pentachlorodibenzofuran
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
1 100F 2012
000062-44-2
Phenacetin
(NB: Overall evaluation upgraded to Group 1 with
supporting evidence from other relevant data)
1 24, Sup 7,
100A 2012
Phenacetin, analgesic mixtures containing 1 Sup 7, 100A 2012
014596-37-3 Phosphorus-32, as phosphate 1 78, 100D 2012
007440-07-5 Plutonium 1 78, 100D 2012
Radioiodines, including iodine-131 1 78, 100D 2012
Radionuclides, alpha-particle-emitting, internally
deposited
(NB: Specific radionuclides for which there is sufficient
evidence in humans are also listed individually as
Group 1 agents)
1 78, 100D 2012
Radionuclides, beta-particle-emitting, internally deposited
(NB: Specific radionuclides for which there is sufficient
evidence in humans are also listed individually as
Group 1 agents)
1 78, 100D 2012
013233-32-4 Radium-224 and its decay products 1 78, 100D 2012
013982-63-3 Radium-226 and its decay products 1 78, 100D 2012
015262-20-1 Radium-228 and its decay products 1 78, 100D 2012
010043-92-2 Radon-222 and its decay products 1 43, 78, 100D 2012
Rubber manufacturing industry 1 28, Sup 7,
100F 2012
CAS No Agent Group Volume Year
Salted fish, Chinese-style 1 56, 100E 2012
Schistosoma haematobium (infection with) 1 61, 100B 2012
013909-09-6 Semustine [1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-
nitrosourea, Methyl-CCNU] 1 Sup 7, 100A 2012
068308-34-9 Shale oils 1 35, Sup 7,
100F 2012
014808-60-7 Silica dust, crystalline, in the form of quartz or cristobalite 1 68, 100C 2012
Solar radiation 1 55, 100D 2012
Soot (as found in occupational exposure of chimney
sweeps) 1 35, Sup 7,
100F 2012
000505-60-2 Sulfur mustard 1 9, Sup 7,
100F 2012
010540-29-1
Tamoxifen
(NB: There is also conclusive evidence that tamoxifen
reduces the risk of contralateral breast cancer in breast
cancer patients)
1 66, 100A 2012
001746-01-6 2,3,7,8-Tetrachlorodibenzo-para-dioxin 1 69, 100F 2012
000052-24-4 Thiotepa 1 50, 100A 2012
007440-29-1 Thorium-232 and its decay products 1 78, 100D 2012
Tobacco, smokeless 1 89, 100E 2012
Tobacco smoke, second-hand 1 83, 100E 2012
Tobacco smoking 1 83, 100E 2012
000095-53-4 ortho-Toluidine 1 77, 99, 100F 2012
000299-75-2 Treosulfan 1 26, Sup 7,
100A 2012
Ultraviolet radiation (wavelengths 100-400 nm,
encompassing UVA, UVB, and UVC) 1 100D 2012
Ultraviolet-emitting tanning devices 1 100D 2012
000075-01-4 Vinyl chloride 1 97, 100F 2012
Wood dust 1 62, 100C 2012
X- and Gamma-Radiation 1